Journal: Molecular Medicine Reports
Article Title: NMDA receptors promote neurogenesis in the neonatal rat subventricular zone following hypoxic-ischemic injury
doi: 10.3892/mmr.2015.4501
Figure Lengend Snippet: Comparison of the number of DCX-positive cells in the subventricular zone (SVZ) at different time points (2, 6, 24 and 48 h) after hypoxic-ischemic in the sham group, hypoxic-ischemia (labeled 'model') group, hypoxic-ischemia+treatment with MK-801 group, hypoxic-ischemia+treatment with Ro25-6981 group, and hypoxic-ischemia+treatment with NVP-AAM077 group. Data are presented as mean ± standard deviation. Positive cell counts in five 100×100 μ m 2 areas in the SVZ of three serially sectioned brains at each tested time point. * P<0.05, ** P<0.01, and △ P<0.001 vs. hypoxic-ischemia group. #P<0.05, ## P<0.01, and ★ P<0.001 vs. hypoxic-ischemia+treatment with MK group.
Article Snippet: Selective non-competitive NMDAR antagonist MK-801 (M107), NR2A antagonist NVP-AAM077 (P1999), and NR2B antagonist Ro25-6981 (R7150) were purchased from Sigma-Aldrich (St. Louis, MO, USA).
Techniques: Labeling, Standard Deviation